14-3-3 beta / YWHAB 항체 (PE), 생쥐 단클론항체

  • 14-3-3 beta / YWHAB Antibody (PE), Mouse MAb, Flow cytometric
데이터시트리뷰관련제품프로토콜
휴먼 YWHAB 항체 제품 정보
면역원:Recombinant Human 14-3-3 beta / YWHAB protein (Catalog#10843-H09E)
Clone ID:03
면역글로불린(Ig) 유형:Mouse IgG2b
농도:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
제조방법:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 14-3-3 beta / YWHAB (rh 14-3-3 beta / YWHAB; Catalog#10843-H09E; NP_003395.1; Met 1-Asn 246) and conjugated with PE under optimum conditions, the unreacted PE was removed.
휴먼 YWHAB Antibody FC Application Image
14-3-3 beta / YWHAB Antibody (PE), Mouse MAb, Flow cytometric
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Caption:
Profile of anti-YWHAB reactivity on HepG2 cells analyzed by flow cytometry.
Other YWHAB Antibody Products
14-3-3 beta/YWHAB 연구배경

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

휴먼 14-3-3 beta/YWHAB 참고자료
  • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
  • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
  • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.
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    Cat No: 10843-MM03-P-25
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