14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Human

Cat: HG10842-M

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14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Human General Information

Gene

Species
Human
NCBI Ref Seq
RefSeq ORF Size
768 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide.

Plasmid

Sequencing Primers
M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.

Screening

Antibiotic in E.coli
Ampicillin

Storage & Shipping

Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

14-3-3 epsilon cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Human Alternative Names

14-3-3E cDNA ORF Clone, Human;HEL2 cDNA ORF Clone, Human;KCIP-1 cDNA ORF Clone, Human;MDCR cDNA ORF Clone, Human;MDS cDNA ORF Clone, Human

14-3-3 epsilon Background Information

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 1% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.
Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
References
  • Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
  • Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
  • Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.
  • 14-3-3 epsilon cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Rhesus CG90436-G
    14-3-3 epsilon cDNA ORF Clone, Rhesus, untagged CG90436-UT
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90436-ACG
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-GFPSpark® tag CG90436-ANG
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90436-ACR
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-OFPSpark® tag CG90436-ANR
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90436-CF
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90436-NF
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-His tag CG90436-CH
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-His tag CG90436-NH
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-HA tag CG90436-CY
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-HA tag CG90436-NY
    14-3-3 epsilon cDNA ORF Clone, Rhesus, C-Myc tag CG90436-CM
    14-3-3 epsilon cDNA ORF Clone, Rhesus, N-Myc tag CG90436-NM

    14-3-3 epsilon cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Rat RG80090-G
    14-3-3 epsilon cDNA ORF Clone, Rat, untagged RG80090-UT
    14-3-3 epsilon cDNA ORF Clone, Rat, C-GFPSpark® tag RG80090-ACG
    14-3-3 epsilon Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80090-ACGLN
    14-3-3 epsilon cDNA ORF Clone, Rat, N-GFPSpark® tag RG80090-ANG
    14-3-3 epsilon cDNA ORF Clone, Rat, C-OFPSpark® tag RG80090-ACR
    14-3-3 epsilon cDNA ORF Clone, Rat, N-OFPSpark® tag RG80090-ANR
    14-3-3 epsilon cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80090-CF
    14-3-3 epsilon cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80090-NF
    14-3-3 epsilon cDNA ORF Clone, Rat, C-His tag RG80090-CH
    14-3-3 epsilon cDNA ORF Clone, Rat, N-His tag RG80090-NH
    14-3-3 epsilon cDNA ORF Clone, Rat, C-HA tag RG80090-CY
    14-3-3 epsilon cDNA ORF Clone, Rat, N-HA tag RG80090-NY
    14-3-3 epsilon cDNA ORF Clone, Rat, C-Myc tag RG80090-CM
    14-3-3 epsilon cDNA ORF Clone, Rat, N-Myc tag RG80090-NM
    14-3-3 epsilon qPCR Primer Pairs, Rat RP300086

    14-3-3 epsilon cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone in Cloning Vector, Mouse MG50691-G
    14-3-3 epsilon cDNA ORF Clone, Mouse, untagged MG50691-UT
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50691-ACG
    14-3-3 epsilon Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50691-ACGLN
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-GFPSpark® tag MG50691-ANG
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50691-ACR
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-OFPSpark® tag MG50691-ANR
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50691-CF
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50691-NF
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-His tag MG50691-CH
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-His tag MG50691-NH
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-HA tag MG50691-CY
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-HA tag MG50691-NY
    14-3-3 epsilon cDNA ORF Clone, Mouse, C-Myc tag MG50691-CM
    14-3-3 epsilon cDNA ORF Clone, Mouse, N-Myc tag MG50691-NM
    14-3-3 epsilon qPCR Primer Pairs, Mouse MP200667

    14-3-3 epsilon cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    14-3-3 epsilon cDNA ORF Clone, Human, untagged HG10842-UT
    14-3-3 epsilon Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10842-ACGLN
    14-3-3 epsilon cDNA ORF Clone, Human, C-GFPSpark® tag HG10842-ACG
    14-3-3 epsilon cDNA ORF Clone, Human, N-GFPSpark® tag HG10842-ANG
    14-3-3 epsilon cDNA ORF Clone, Human, C-OFPSpark® tag HG10842-ACR
    14-3-3 epsilon cDNA ORF Clone, Human, N-OFPSpark® tag HG10842-ANR
    14-3-3 epsilon cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10842-CF
    14-3-3 epsilon cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10842-NF
    14-3-3 epsilon cDNA ORF Clone, Human, C-His tag HG10842-CH
    14-3-3 epsilon cDNA ORF Clone, Human, N-His tag HG10842-NH
    14-3-3 epsilon cDNA ORF Clone, Human, C-HA tag HG10842-CY
    14-3-3 epsilon cDNA ORF Clone, Human, N-HA tag HG10842-NY
    14-3-3 epsilon cDNA ORF Clone, Human, C-Myc tag HG10842-CM
    14-3-3 epsilon cDNA ORF Clone, Human, N-Myc tag HG10842-NM
    14-3-3 epsilon qPCR Primer Pairs, Human HP100740
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