YWHAH  항체

All YWHAH Reagents

반응성: Human  
신청: ELISA  
10847-RP01-400
10847-RP01-200
10847-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
    반응성: Human  
    신청: ELISA  WB  IP  
    10847-RP02-50
    10847-RP02-200
    10847-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    • Slide 1
    반응성: Human  
    신청: ELISA  WB  IP  
    10847-MM06-50
    10847-MM06-200
    10847-MM06-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    • Slide 1
    • Slide 1

    Browse YWHAH Products by

    YWHAH Related Area

    YWHAH 요약 및 단백질 정보

    YWHAH 배경

    유전자 요약: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder
    General information above from NCBI
    촉매 활성: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate.
    효소 조절: Inhibited by vanadate.
    하부단위 구조: Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with ARHGEF28 and CDK16 (By similarity). Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with KCNK18 in a phosphorylation-dependent manner. Interacts with SAMSN1 (By similarity). Interacts with the 'Ser-241' phosphorylated form of PDPK1. {ECO:0000250, ECO:0000269|PubMed:11266503, ECO:0000269|PubMed:12177059, ECO:0000269|PubMed:14504289, ECO:0000269|PubMed:15696159, ECO:0000269|PubMed:17085597, ECO:0000269|PubMed:19172738}.
    세포하 위치: Endoplasmic reticulum membrane; Multi-pass membrane protein.
    조직 특이성: Expressed mainly in the brain and present in other tissues albeit at lower levels.
    번역 후: Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. {ECO:0000250}.
    질병과의 관련성: Neutropenia severe congenital autosomal recessive 4 (SCN4) [MIM:612541]: A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Dursun syndrome (DURSS) [MIM:612541]: A disease characterized by pulmonary arterial hypertension, cardiac abnormalities including secundum-type atrial septal defect, intermittent neutropenia, lymphopenia, monocytosis and anemia. Note=The disease is caused by mutations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the 14-3-3 family. {ECO:0000305}.
    General information above from UniProt

    YWHAH 대체 이름

    YWHA1, [homo-sapiens]
    14-3-3 eta,LL22NC03-44A4.1,YWHA1,YWHAH, [human]
    14-3-3 protein eta,Ywhah,OTTMUSP00000017560,14-3-3 eta, [mouse]

    YWHAH 관련 연구

  • Wakui H, et al. (1997) Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein. J Biol Chem. 272(13): 8153-6.
  • Toyooka K, et al. (2002) Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain. Brain Res Mol Brain Res. 100(1-2): 13-20.
  • Kim YS, et al. (2005) Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation. Endocrinology. 146(7): 3133-40.
  • Grover D, et al. (2009) Family-based association of YWHAH in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 150B(7): 977-83.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".