14-3-3 sigma/Stratifin/YWHAS  유전자

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    14-3-3 sigma/Stratifin/YWHAS 요약 및 단백질 정보

    14-3-3 sigma/Stratifin/YWHAS 배경

    유전자 요약: OMIM - description for 14-3-3 sigma (Stratifin, YWHAS):
    General information above from NCBI
    하부단위 구조: Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:22634725}.
    세포하 위치: Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
    조직 특이성: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
    번역 후: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.
    염기서열 유사성: Belongs to the 14-3-3 family. {ECO:0000305}.
    General information above from UniProt

    14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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