Anti-4-1BBL Antibody

Cat: 50067-R014

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All 4-1BBL Reagents

Anti-4-1BBL Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-4-1BBL Antibody
Species reactivity
Reacts with: Mouse
Mouse 4-1BBL
Recombinant Mouse TNFSF9 protein (Catalog#50067-M07H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNFSF9 / 4-1BBL (rM TNFSF9; Catalog#50067-M07H; Arg 104-Glu 309; NP_033430.1).
Monoclonal Rabbit IgG Clone #014
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-4-1BBL Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:1000-1:2000  
ICC-IF 1:50-1:1000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-4-1BBL Antibody (Rabbit Monoclonal antibody) Images

Mouse CD137L/4-1BBL/TNFSF9 Immunohistochemistry(IHC) 5472
Confocal immunofluorescence analysis of Mouse TNFSF9 in RAW264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Mouse TNFSF9 monoclonal antibody (1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to plasma membrane.
Mouse CD137L/4-1BBL/TNFSF9 Flow Cytometry (FC) 14788
Flow cytometric analysis of Mouse TNFSF9 expression on Raw264.7 cells. Cells were stained with purified anti-Mouse TNFSF9, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-4-1BBL Antibody Alternative Names

Anti-4-1BB-L Antibody;Anti-4-1BBL Antibody;Anti-AI848817 Antibody;Anti-Cd137l Antibody;Anti-Ly63l Antibody

4-1BBL Background Information

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy
Full Name
tumor necrosis factor (ligand) superfamily, member 9
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-4-1BBL Antibody Rabbit Polyclonal ELISA 80166-T16
    Anti-4-1BBL Antibody Rabbit Polyclonal ELISA 80166-RP01
    Anti-4-1BBL Antibody Rabbit Polyclonal ELISA 50067-RP02
    Anti-4-1BBL Antibody (PerCP) Rabbit Monoclonal FCM 50067-R014-C
    Anti-4-1BBL Antibody Rabbit Polyclonal ELISA 50067-RP01
    Anti-4-1BBL Antibody (APC) Rabbit Monoclonal FCM 50067-R014-A
    Anti-4-1BBL Antibody (FITC) Rabbit Monoclonal FCM 50067-R014-F
    Anti-4-1BBL Antibody (PE) Rabbit Monoclonal FCM 50067-R014-P
    Anti-4-1BBL Antibody Rabbit Polyclonal ELISA 50067-T16
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