쥐 4-1BBL / CD137L / TNFSF9 단백질 (His 태그)

  • Mouse 4-1BBL / CD137L / TNFSF9 Protein (His Tag) SDS-PAGE
데이터시트리뷰관련제품프로토콜
 4-1BBL 단백질 제품 정보
동의어:4-1BB-L,4-1BBL,AI848817,Cd137l,Ly63l
단백질 구조:A DNA sequence encoding the extracellular domain (Arg 104-Glu 309) of mouse TNFSF9 (NP_033430.1) precursor was expressed with a N-terminal polyhistidine tag.
:Mouse
발현 숙주:Human Cells
양식 및 배송:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
 4-1BBL 단백질 품질 관리 검사
순도:> 97 % as determined by SDS-PAGE
생리활성:Measured by its binding ability in a functional ELISA . Immobilized recombinant mouse 4-1BB Ligand at 20 μg/ml (100ul/well) can bind human 4-1BB with a linear range of 15.6-500 ng/ml .
내독소:< 1.0 EU per μg of the protein as determined by the LAL method
안정성:Samples are stable for up to twelve months from date of receipt at -70℃
예상된 N 말단(N Terminal):His
분자량:The secreted recombinant mouse TNFSF9 consists of 222 amino acids and has a calculated molecular mass of 25 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 40-45 kDa protein in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
 4-1BBL 단백질 사용 가이드
보관:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
복원:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
 4-1BBL Protein SDS-PAGE
Mouse 4-1BBL / CD137L / TNFSF9 Protein (His Tag) SDS-PAGE
Other 4-1BBL Recombinant Protein Products
50067-M07H
CD137L/4-1BBL/TNFSF9 연구배경

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 CD137L/4-1BBL/TNFSF9 참고자료
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
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    Cat No: 50067-M07H-20
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    Datasheet & Documentation

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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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