4-1BBL / CD137L / TNFSF9 항체 (PerCP), 토끼 단클론항체

  • 4-1BBL / CD137L / TNFSF9 Antibody (PerCP), Rabbit MAb, Flow cytometric analysis
데이터시트리뷰관련제품프로토콜
 TNFSF9 항체 제품 정보
면역원:Recombinant Mouse 4-1BBL / CD137L / TNFSF9 protein (Catalog#50067-M07H)
Clone ID:014
면역글로불린(Ig) 유형:Rabbit IgG
농도:10 μl/Test, 0.1 mg/ml
내독소:
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL / CD137L / TNFSF9 (rM 4-1BBL / CD137L / TNFSF9; Catalog#50067-M07H; NP_033430.1; Arg 104-Glu 309) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
 TNFSF9 Antibody FC Application Image
4-1BBL / CD137L / TNFSF9 Antibody (PerCP), Rabbit MAb, Flow cytometric analysis
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Caption:
Profile of anti-TNFSF9 reactivity on Raw264.7 cells analyzed by flow cytometry. Cells should be Fc-blocked by treatment with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) prior to staining, washed, then stained with PerCP Rabbit anti-TNFSF9.
Other TNFSF9 Antibody Products
CD137L/4-1BBL/TNFSF9 연구배경

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 CD137L/4-1BBL/TNFSF9 참고자료
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
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    Cat No: 50067-R014-C-25
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    Datasheet & Documentation

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