4E-BP1 / EIF4EBP1 항체, 토끼 다클론항체

    데이터시트리뷰관련제품프로토콜
    휴먼 EIF4EBP1 항체 제품 정보
    면역원:Recombinant Human 4E-BP1 / EIF4EBP1 protein (Catalog#10022-H07E)
    Clone ID:
    면역글로불린(Ig) 유형:Rabbit IgG
    농도:
    내독소:
    Formulation:0.2 μm filtered solution in PBS
    제조방법:Produced in rabbits immunized with purified, recombinant Human 4E-BP1 / EIF4EBP1 (rh EIF4EBP1; Catalog#10022-H07E; NP_004086.1; Ser2-Ile118). Total IgG was purified by Protein A affinity chromatography.
    Other EIF4EBP1 Antibody Products
    4E-BP1/EIF4EBP1 연구배경

    The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. Binding of eIF4E to eIF4G is inhibited in a competitive manner by 4E-BP1. Phosphorylation of 4E-BP1 decreases the affinity of this protein for eIF4E, thus favouring the binding of eIF4G and enhancing translation. 4E-BP1 is important for beta-cell survival under endoplasmic reticulum (ER) stress. 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recently, 4E-BP1 was found to be a key factor, which converges several oncogenic signals, phosphorylates the molecules, and drives the downstream proliferative signals. Recent studies showed that high expression of phosphorylated 4E-BP-1 (p-4E-BP1) is associated with poor prognosis, tumor progression, or nodal metastasis in different human cancers.

    휴먼 4E-BP1/EIF4EBP1 참고자료
  • Azar R, et al. (2008) Phosphatidylinositol 3-kinase-dependent transcriptional silencing of the translational repressor 4E-BP1. Cell Mol Life Sci. 65(19): 3110-7.
  • Tominaga R, et al. (2010) The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions. Cell Biochem Funct. 28(5): 387-93.
  • Ayuso MI, et al. (2010) New hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stress. J Biol Chem. 285(45): 34355-63.
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    Cat No: 10022-RP01-100
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    Datasheet & Documentation

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