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AAA ATPases

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AAA proteins: AAA or AAA+ is an abbreviation for ATPases Associated with diverse cellular Activities. They share a common conserved module of approximately 230 amino acid residues. This is a large, functionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent remodeling or translocation of macromolecules. AAA proteins couple chemical energy provided by ATP hydrolysis to conformational changes which are transduced into mechanical force exerted on a macromolecular substrate. AAA proteins are functionally and organizationally diverse, and vary in activity, stability, and mechanism. Members of the AAA family are found in all organisms and they are essential for many cellular functions. They are involved in processes such as DNA replication, protein degradation, membrane fusion, microtubule severing, peroxisome biogenesis, signal transduction and the regulation of gene expression. [Source: Wikipedia]

A subset of :ATPases

AAA ATPases members:
Approved Symbol Approved Name Previous Symbols Synonyms Chromosome Accession Numbers RefSeq IDs Gene family description
AFG3L1P AFG3 like matrix AAA peptidase subunit 1, pseudogene AFG3, AFG3L1 16q24.3 AJ001495 NR_003226 AAA ATPases
AFG3L2 AFG3 like matrix AAA peptidase subunit 2 SCA28 SPAX5 18p11.21 Y18314 NM_006796 AAA ATPases
ATAD1 ATPase family, AAA domain containing 1 FLJ14600 10q23.31 AL834370 NM_032810 AAA ATPases
ATAD2 ATPase family, AAA domain containing 2 PRO2000, DKFZp667N1320, MGC5254, MGC29843, CT137 8q24.13 BC019909 NM_014109 AAA ATPases
ATAD2B ATPase family, AAA domain containing 2B KIAA1240 2p24.1-p23.3 AB033066 NM_017552 AAA ATPases
ATAD3A ATPase family, AAA domain containing 3A FLJ10709 1p36.33 AK025865 NM_018188 AAA ATPases
ATAD3B ATPase family, AAA domain containing 3B TOB3, KIAA1273 1p36.33 AL834179 NM_031921 AAA ATPases
ATAD3C ATPase family, AAA domain containing 3C FLJ34599 1p36.33 AK091918 NM_001039211 AAA ATPases
ATAD5 ATPase family, AAA domain containing 5 C17orf41 FLJ12735, FRAG1, ELG1 17q11.2 NM_024857 AAA ATPases
BCS1L BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Hs.6719, BCS, h-BCS, BJS 2q35 AF026849 NM_004328 AAA ATPases
CHTF18 chromosome transmission fidelity factor 18 C16orf41 CHL12, C321D2.4, Ctf18 16p13.3 BC018184 NM_022092 AAA ATPases
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin HSP78, SKD3, FLJ13152, ANKCLB 11q13.4 BC006404 NM_030813 AAA ATPases
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 19p13.3 Z50853 NM_006012 AAA ATPases
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 15q22.31 AJ006267 NM_006660 AAA ATPases
FIGN fidgetin, microtubule severing factor 2q24.3 AK001267 NM_018086 AAA ATPases
FIGNL1 fidgetin like 1 7p12.2 AK023142 NM_001042762 AAA ATPases
FIGNL2 fidgetin like 2 12q13.13 AK129980 NM_001013690 AAA ATPases
IQCA1 IQ motif containing with AAA domain 1 IQCA FLJ22527, DRC11 2q37.2-q37.3 AK026180 NM_024726 AAA ATPases
KATNA1 katanin catalytic subunit A1 6q25.1 AF056022 NM_007044 AAA ATPases
KATNAL1 katanin catalytic subunit A1 like 1 MGC2599 13q12.3 AK097423 NM_032116 AAA ATPases
KATNAL2 katanin catalytic subunit A1 like 2 MGC33211, DKFZP667C165 18q21.1 BC034999 NM_031303 AAA ATPases
LONP1 lon peptidase 1, mitochondrial PRSS15 LonHS, hLON, PIM1 19p13.2 U02389 NM_004793 AAA ATPases
LONP2 lon peptidase 2, peroxisomal MGC4840, LONP, LONPL 16q12.1 AJ548761 NM_031490 AAA ATPases
NSF N-ethylmaleimide sensitive factor, vesicle fusing ATPase SKD2 17q21.31 NM_006178 AAA ATPases
NVL nuclear VCP-like NVL2 1q42.11 U78772 NM_002533 AAA ATPases
ORC1 origin recognition complex subunit 1 ORC1L HSORC1, PARC1 1p32.3 NM_004153 AAA ATPases
ORC4 origin recognition complex subunit 4 ORC4L HsORC4, Orc4p 2q23.1 AF022108 NM_181742 AAA ATPases
PEX1 peroxisomal biogenesis factor 1 ZWS1, ZWS 7q21.2 AF026086 NM_000466 AAA ATPases
PEX6 peroxisomal biogenesis factor 6 PXAAA1, PAF-2 6p21.1 U56602 NM_000287 AAA ATPases
PSMC1 proteasome 26S subunit, ATPase 1 S4, p56 14q32.11 L02426 NM_002802 AAA ATPases
PSMC2 proteasome 26S subunit, ATPase 2 MSS1, S7, Nbla10058 7q22.1 D11094 NM_002803 AAA ATPases
PSMC3 proteasome 26S subunit, ATPase 3 TBP1, TBP-1 11p11.2 M34079 NM_002804 AAA ATPases
PSMC4 proteasome 26S subunit, ATPase 4 MIP224 TBP7, S6, MGC8570, MGC13687, MGC23214, TBP-7 19q13.11-q13.13 U27515 NM_006503 AAA ATPases
PSMC5 proteasome 26S subunit, ATPase 5 SUG1, p45/SUG, TBP10, p45, S8, TRIP1, SUG-1 17q23.3 L38810 NM_002805 AAA ATPases
PSMC6 proteasome 26S subunit, ATPase 6 p42 14q22.1 NM_002806 AAA ATPases
RFC1 replication factor C subunit 1 A1, PO-GA, RFC140, MHCBFB 4p14 L23320 NM_002913 AAA ATPases
RFC2 replication factor C subunit 2 A1, RFC40 7q11.23 NM_181471 AAA ATPases
RFC3 replication factor C subunit 3 RFC38, MGC5276 13q13.2 NM_002915 AAA ATPases
RFC4 replication factor C subunit 4 A1, RFC37 3q27.3 NM_002916 AAA ATPases
RFC5 replication factor C subunit 5 RFC36 12q24.23 NM_007370 AAA ATPases
RUVBL1 RuvB like AAA ATPase 1 TIP49, NMP238, RVB1, TIP49a, Pontin52, ECP54, TIH1, Rvb1, INO80H 3q21.3 AF070735 AAA ATPases
RUVBL2 RuvB like AAA ATPase 2 RVB2, TIP48, TIP49b, Reptin52, ECP51, TIH2, INO80J, Rvb2 19q13.33 AF155138 AAA ATPases
SPAST spastin SPG4 FSP2, ADPSP, KIAA1083 2p22.3 AJ246001 NM_199436 AAA ATPases
SPATA5 spermatogenesis associated 5 SPAF, AFG2 4q28.1 AF361489 NM_145207 AAA ATPases
SPATA5L1 spermatogenesis associated 5 like 1 MGC5347, FLJ12286 15q21.1 AK023232 NM_024063 AAA ATPases
SPG7 SPG7, paraplegin matrix AAA peptidase subunit CMAR CAR, SPG5C 16q24.3 Y16610 NM_003119 AAA ATPases
TRIP13 thyroid hormone receptor interactor 13 16E1BP 5p15.33 L40384 NM_004237 AAA ATPases
VCP valosin containing protein IBMPFD, p97 9p13.3 AC004472 NM_007126 AAA ATPases
VPS4A vacuolar protein sorting 4 homolog A VPS4, VPS4-1, FLJ22197, SKD2, SKD1, SKD1A 16q23.1 AF112215 NM_013245 AAA ATPases
VPS4B vacuolar protein sorting 4 homolog B SKD1 VPS4-2, SKD1B 18q21.33 AF038960 NM_004869 AAA ATPases
WRNIP1 Werner helicase interacting protein 1 WHIP, FLJ22526, bA420G6.2 6p25.2 AB056152 NM_130395 AAA ATPases
YME1L1 YME1 like 1 ATPase 10p12.1 AJ132637 NM_139312 AAA ATPases
MDN1 midasin AAA ATPase 1 KIAA0301, Rea1 6q15 AF503925 AAA ATPases
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