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    ABCB9 요약 및 단백질 정보

    ABCB9 배경

    하부단위 구조: Homodimer. {ECO:0000269|PubMed:15863492}.
    도메인: The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. {ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:20377823}.
    세포하 위치: Lysosome membrane {ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514}. Note=May be located in membrane rafts.
    조직 특이성: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. {ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:17977821}.
    유도: Not induced by interferon-gamma. {ECO:0000269|PubMed:11011155}.
    염기서열 유사성: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. {ECO:0000305}.; Contains 1 ABC transmembrane type-1 domain. {ECO:0000255|PROSITE-ProRule:PRU00441}.; Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule:PRU00434}.
    General information above from UniProt

    ABCB9 대체 이름

    TAPL,EST122234, [homo-sapiens]
    TAPL,mKIAA1520, [mus-musculus]

    ABCB9 관련 연구

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