ABCF1: ABCF1 Protein | ABCF1 Antibody

ABCF1 Gene family

ABCF1 Protein

ABCF1 protein function

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.

ABCF1 protein expression

Tissue specificity

Ubiquitous.

Induction

By TNF in cultured synoviocytes.

ABCF1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    845.00
  • Mass (Da)
    95.00

ABCF1 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]