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    ABHD14B 요약 및 단백질 정보

    ABHD14B 배경

    하부단위 구조: May interact with TAF1.
    세포하 위치: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.
    조직 특이성: Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney. {ECO:0000269|PubMed:14672934}.
    염기서열 유사성: Belongs to the AB hydrolase superfamily. ABHD14 family. {ECO:0000305}.
    General information above from UniProt

    ABHD14B belongs to the AB hydrolase superfamily, ABHD14 family. It can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney. ABHD14B has hydrolase activity towards p-nitrophenyl butyrate (in vitro) and may interact with TAF1. It may activate transcription. Recombinant human ABHD14B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. ABHD14B contains an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. In molecular biology, the alpha/beta hydrolase fold is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The Ab hydrolase domain containing gene subfamily is comprised of 15 mostly uncharacterized members.

    ABHD14B 대체 이름

    CIB,HEL-S-299, [homo-sapiens]
    abhydrolase domain-containing protein 14B,CCG1-interacting factor B,cell cycle gene 1-interacting factor B,CIB, [human]
    1810013B01Rik,abhydrolase domain-containing protein 14B,CCG1-interacting factor B, [mouse]
    1810013B01Rik, [mus-musculus]

    ABHD14B 관련 연구

  • Mehrle A, et al. (2006) The LIFEdb database in 2006. Nucleic Acids Res. 34:D415-8.
  • Wan D, et al. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci. 101(44):15724-9.
  • Wiemann S, et al. (2004) From ORFeome to biology: a functional genomics pipeline. Genome Res. 14 (10B):2136-44.
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