ADAM15 항체 (PE), 토끼 단클론항체

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Human ADAM15 항체 제품 정보
면역원:Recombinant Human ADAM15 protein (Catalog#10517-H08H)
Clone ID:007
면역글로불린(Ig) 유형:Rabbit IgG
농도:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Human ADAM15 (rh ADAM15; Catalog#10517-H08H; NP_997074.1; Met 1-Thr 696) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human ADAM15 항체 사용 가이드
특이성:Human ADAM15
No cross-reactivity in ELISA with
Human ADAM12
Mouse ADAM9
Mouse ADAM15
적용:FCM
보관:This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Human ADAM15 Antibody FC Application Image
ADAM15 Antibody (PE), Rabbit MAb, Flow cytometric
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Caption:
Profile of anti-ADAM15 reactivity on MCF-7 cells analyzed by flow cytometry.
Other ADAM15 Antibody Products
ADAM15 연구배경

ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

Human ADAM15 참고자료
  • Poghosyan Z, et al. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 277(7): 4999-5007.
  • Carl-McGrath S, et al. (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26(1): 17-24.
  • Najy AJ, et al. (2008) ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res. 68(4): 1092-9.
  • Maretzky T, et al. (2009) Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J. 420(1): 105-13.
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    Cat No: 10517-R007-P-50
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    • Human ADAM15 Flow Cytometry (FC) 2644
    • ADAM15 Antibody (PE), Rabbit MAb, Flow cytometric
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