ADAM15 항체, 토끼 다클론 항체, Antigen Affinity Purified

    데이터시트리뷰관련제품프로토콜
     ADAM15 항체 제품 정보
    면역원:Recombinant Mouse ADAM15 protein (Catalog#51001-M08H)
    Clone ID:
    면역글로불린(Ig) 유형:Rabbit IgG
    농도:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    제조방법:Produced in rabbits immunized with purified, recombinant Mouse ADAM15 (rM ADAM15; Catalog#51001-M08H; O88839-1; Met 1-Thr 697). ADAM15 specific IgG was purified by Mouse ADAM15 affinity chromatography.
    Other ADAM15 Antibody Products
    ADAM15 연구배경

    ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.

     ADAM15 참고자료
  • Poghosyan Z, et al. (2002) Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases. J Biol Chem. 277(7): 4999-5007.
  • Carl-McGrath S, et al. (2005) The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 26(1): 17-24.
  • Najy AJ, et al. (2008) ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction. Cancer Res. 68(4): 1092-9.
  • Maretzky T, et al. (2009) Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. Biochem J. 420(1): 105-13.
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