After search, choose a molecule or a kind of categories listed in the left to narrow down your filter. If you have any problems, please contact us!
Text Size:AAA

AK2 / Adenylate kinase 2 Antibody, Rabbit MAb

데이터시트리뷰관련제품프로토콜
Human AK2 항체 제품 정보
면역원:Recombinant Human AK2 protein (Catalog#13146-H20B)
Clone ID:025
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met1-Ile239).
Human AK2 항체 사용 가이드
특이성:Human AK2
적용:WB, ELISA, IHC-P

WB: 1-10 μg/ml

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human AK2. The detection limit for Human AK2 is approximately 0.00975 ng/well.

IHC-P: 1-10 μg/mL

보관:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human AK2 Antibody WB Application Image
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb
Human AK2 Antibody IHC Application Image
[이미지를 확대하려면 클릭]
Caption:
Immunochemical staining of human AK2 in human kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
[이미지를 확대하려면 클릭]
Caption:
Immunochemical staining of human AK2 in human liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
Other AK2 Antibody Products
AK2 / Adenylate kinase 2 연구배경

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

Human AK2 / Adenylate kinase 2 참고자료
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
  • Product nameProduct name
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".