Text Size:AAA

AK4 / Adenylate Kinase 4 / AK3L1  단백질

All AK4 Reagents

Browse AK4 / Adenylate Kinase 4 / AK3L1 Products by

AK4 / Adenylate Kinase 4 / AK3L1 관련 경로

AK4 / Adenylate Kinase 4 / AK3L1 관련 제품

AK4 / Adenylate Kinase 4 / AK3L1 관련 제품

Featured Reagent Products

AK4 / Adenylate Kinase 4 / AK3L1 요약 및 단백질 정보

AK4 / Adenylate Kinase 4 / AK3L1 배경

유전자 요약: This AK3L1 gene encodes a member of the adenylate kinase family of enzymes. AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this AK3L1 gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]
General information above from NCBI
촉매 활성: NTP + AMP = NDP + ADP.
하부단위 구조: Monomer.
도메인: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
세포하 위치: Mitochondrion matrix.
조직 특이성: Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.
염기서열 유사성: Belongs to the adenylate kinase family. AK3 subfamily.C
General information above from UniProt

Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.

AK4 / Adenylate Kinase 4 / AK3L1 대체 이름

AK4 / Adenylate Kinase 4 / AK3L1 관련 연구

주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".