ALK-2/ACVR1  단백질

All ALK-2  Reagents

제품 설명: Active  
발현 숙주: Human Cells  
10227-H03H-200
10227-H03H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Baculovirus-Insect Cells  
10227-H08B-200
10227-H08B-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
제품 설명: Active  
발현 숙주: Human Cells  
50297-M03H-200
50297-M03H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
80118-R02H-200
80118-R02H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
90058-C02H-200
90058-C02H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
70048-D08H-200
70048-D08H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
70048-D02H-200
70048-D02H-100
200 µg 
100 µg 
Add to Cart
  • Slide 1

Browse ALK-2/ACVR1 Products by

ALK-2/ACVR1 Related Area

ALK-2/ACVR1 관련 경로

ALK-2/ACVR1 요약 및 단백질 정보

ALK-2/ACVR1 배경

유전자 요약: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
General information above from NCBI
촉매 활성: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
보조 인자: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
하부단위 구조: Interacts with FKBP1A. Interacts with FCHO1. {ECO:0000269|PubMed:22484487, ECO:0000269|Ref.6}.
세포하 위치: Membrane; Single-pass type I membrane protein.
조직 특이성: Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
질병과의 관련성: DISEASE: Fibrodysplasia ossificans progressiva (FOP) [MIM:135100]: A rare autosomal dominant connective tissue disorder resulting in skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to a debilitating ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible. {ECO:0000269|PubMed:16642017, ECO:0000269|PubMed:19085907, ECO:0000269|PubMed:19330033}. Note=The disease is caused by mutations affecting the gene represented in this entry.
염기서열 유사성: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. {ECO:0000305}.; Contains 1 GS domain. {ECO:0000255|PROSITE-ProRule:PRU00585}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).

ALK-2/ACVR1 대체 이름

ALK-2/ACVR1 관련 연구

  • Armes NA,et al. (1997) The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development 124(19): 3797-804.
  • Armes NA, et al. (1999) A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development. J Biol Chem. 274(12):7929-35.
  • Kawai S, et al. (2000) Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity.Biochem Biophys Res Commun. 271(3):682-7.
  • Deng Y, et al. (2009) Efficient highly selective synthesis of methyl 2-(ethynyl)alk-2(E)-enoates and 2-(1'-chlorovinyl)alk-2(Z)-enoates from 2-(methoxycarbonyl)-2,3-allenols. Organic letters 11(10):2169-72.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".