ANTXR2 / CMG2  단백질

All ANTXR2 Reagents

발현 숙주: Human Cells  
  • Slide 1
15762-H02H-100
15762-H02H-50
100 µg 
50 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
51131-M02H-50
51131-M02H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
  • Slide 1
51131-M08H-50
51131-M08H-100
50 µg 
100 µg 
Add to Cart

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ANTXR2 / CMG2 관련 경로

ANTXR2 / CMG2 요약 및 단백질 정보

ANTXR2 / CMG2 배경

하부단위 구조: Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
도메인: Binding to PA seems to be effected through the VWA domain.
세포하 위치: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface.
Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
Isoform 3: Secreted.
조직 특이성: Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
질병과의 관련성: Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. Note=The disease is caused by mutations affecting the gene represented in this entry.
염기서열 유사성: Belongs to the ATR family.
Contains 1 VWFA domain.
General information above from UniProt

ANTXR2 / CMG2 대체 이름

HFS,ISH,JHF,CMG2,CMG-2, [homo-sapiens]
anthrax toxin receptor 2,ANTXR2,CMG-2,CMG2,HFS,ISH,JHF,capillary morphogenesis gene 2 protein,capillary morphogenesis protein 2, [human]
anthrax toxin receptor 2,Antxr2,2310046B19Rik,AW561899,CMG-2,CMG2,cI-35, [mouse]
CMG2,CMG-2,cI-35,AW561899,2310046B19Rik, [mus-musculus]

ANTXR2 / CMG2 관련 연구

주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".