BAFF/BLyS/TNFSF13B  Protein, Antibody, ELISA Kit, cDNA Clone

제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10056-H01H-5
10056-H01H-20
10056-H01H-100
5 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: E. coli  
  • Slide 1
10056-HNAE-50
10056-HNAE-20
50 µg 
20 µg 
Add to Cart
제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
10056-HNCH-500
10056-HNCH-5
10056-HNCH-20
10056-HNCH-100
10056-HNCH-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90267-C01H-50
90267-C01H-20
90267-C01H-100
50 µg 
20 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
70112-D01H-50
70112-D01H-20
50 µg 
20 µg 
Add to Cart

BAFF/BLyS/TNFSF13B Related Area

BAFF/BLyS/TNFSF13B 관련 경로

BAFF/BLyS/TNFSF13B 관련 제품

BAFF/BLyS/TNFSF13B 요약 및 단백질 정보

BAFF/BLyS/TNFSF13B 배경

유전자 요약: The protein encoded by TNFSF13B gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
General information above from NCBI
하부단위 구조: Homotrimer. Isoform 2 heteromultimerizes with isoform 1, probably limiting the amount of functional isoform 1 on the cell surface. Isoform 3 is unlikely form trimers or bind to BAFF receptors. {ECO:0000269|PubMed:12867412, ECO:0000269|PubMed:22749832}.
세포하 위치: Cell membrane; Single-pass type II membrane protein.; Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.
조직 특이성: Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}.
유도: Up-regulated by exposure to IFNG/IFN-gamma. Down-regulated by phorbol myristate acetate/ionomycin treatment.
번역 후: The soluble form derives from the membrane form by proteolytic processing.; Isoform 2 is not efficiently shed from the membrane unlike isoform 1. {ECO:0000250}.; N-glycosylated.
염기서열 유사성: Belongs to the tumor necrosis factor family. {ECO:0000305}.
General information above from UniProt

B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

BAFF/BLyS/TNFSF13B 대체 이름

BAFF/BLyS/TNFSF13B 관련 연구

  • Nardelli B, et al. (2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma. 43(7): 1367-73.
  • Stohl W. (2006) Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr Metab Immune Disord Drug Targets. 6(4): 51-8.
  • Cancro MP, et al. (2009) The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest. 119(5): 1066-73.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".