BMP-2  Protein, Antibody, ELISA Kit, cDNA Clone

제품 설명: Active  
발현 숙주: Human Cells  
10426-H01H-20
10426-H01H-10
20 µg 
10 µg 
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제품 설명: Active  
발현 숙주: E. coli  
10426-HNAE-500
10426-HNAE-5
10426-HNAE-20
10426-HNAE-100
10426-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
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제품 설명: Active  
발현 숙주: E. coli  
63003-ZNAE-5
63003-ZNAE-20
63003-ZNAE-100
5 µg 
20 µg 
100 µg 
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  • Slide 1

BMP-2 Related Area

BMP-2 관련 경로

BMP-2 요약 및 단백질 정보

BMP-2 배경

유전자 요약: The BMP-2 protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. BMP-2, the encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation.
General information above from NCBI
하부단위 구조: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN (By similarity). Interacts with MAFP5 (By similarity). {ECO:0000250|UniProtKB:P21274, ECO:0000250|UniProtKB:Q9QZJ6}.
세포하 위치: Secreted.
조직 특이성: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
염기서열 유사성: Belongs to the TGF-beta family. {ECO:0000305}.
General information above from UniProt

BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.

BMP-2 대체 이름

BMP-2 관련 연구

  • Jiao X, et al. (2007) Heparan sulfate proteoglycans (HSPGs) modulate BMP-2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 282(2):1080-6.
  • Michon F, et al. (2008) BMP-2 and BMP-7 play antagonistic roles in feather induction. Development 135 (16):2797-805.
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