All BTLA reagents are produced in house and quality controlled, including 2 BTLA Antibody, 32 BTLA Gene, 5 BTLA Lysate, 5 BTLA Protein, 2 BTLA qPCR. All BTLA reagents are ready to use.
Recombinant BTLA proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His, C-mouse IgG1-Fc.
BTLAantibodies are validated with different applications, which are WB.
BTLAcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BTLA of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).