BTLA/CD272  단백질

All BTLA Reagents

발현 숙주: Human Cells  
11895-H02H-50
11895-H02H-100
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발현 숙주: Human Cells  
51060-M02H-50
51060-M02H-100
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발현 숙주: Human Cells  
81142-R05H-50
81142-R05H-100
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발현 숙주: Human Cells  
90250-C02H-50
90250-C02H-100
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BTLA/CD272 관련 경로

    BTLA/CD272 요약 및 단백질 정보

    BTLA/CD272 배경

    유전자 요약: BTLA gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
    General information above from NCBI
    하부단위 구조: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM. {ECO:0000269|PubMed:12796776, ECO:0000269|PubMed:14652006, ECO:0000269|PubMed:15568026, ECO:0000269|PubMed:16169851}.
    세포하 위치: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
    번역 후: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. {ECO:0000269|PubMed:15568026}.; N-glycosylated. {ECO:0000269|PubMed:12796776}.
    염기서열 유사성: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

    Immune Checkpoint
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    BTLA/CD272 대체 이름

    BTLA1,CD272, [homo-sapiens]
    B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,BTLA1,CD272, [human]
    A630002H24,B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein, [mouse]
    A630002H24, [mus-musculus]

    BTLA/CD272 관련 연구

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
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