Text Size:AAA

BTLA/CD272  단백질

All BTLA Reagents

발현 숙주: Human Cells  
  • Slide 1
11895-H02H-50
11895-H02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
51060-M02H-50
51060-M02H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
81142-R05H-50
81142-R05H-100
50 µg 
100 µg 
Add to Cart
발현 숙주: Human Cells  
  • Slide 1
90250-C02H-50
90250-C02H-100
50 µg 
100 µg 
Add to Cart

Browse BTLA/CD272 Products by

BTLA/CD272 관련 경로

BTLA/CD272 관련 제품

BTLA/CD272 관련 제품

Featured Reagent Products

BTLA/CD272 요약 및 단백질 정보

BTLA/CD272 배경

유전자 요약: BTLA gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in BTLA gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
General information above from NCBI
하부단위 구조: Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.
세포하 위치: Membrane; Single-pass type I membrane protein (Potential).
번역 후: Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
N-glycosylated.
염기서열 유사성: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

BTLA is a inhibitory molecule which belongs to the Ig superfamily. It down-modulates immune responses. As such, reagents that regulate the binding of BTLA to its ligand or alter BTLA signaling have significant therapeutic promise. BTLA is crucial to understand the mechanism(s) of action of these antibodies before attempting clinical applications. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

BTLA/CD272 대체 이름

BTLA1,CD272, [homo-sapiens]
B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein,BTLA1,CD272, [human]
A630002H24,B and T lymphocyte attenuator,B- and T-lymphocyte attenuator,B- and T-lymphocyte-associated protein, [mouse]
A630002H24, [mus-musculus]

BTLA/CD272 관련 연구

  • Fourcade J, et al. (2012) CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 72(4):887-96.
  • Kojima R, et al. (2011) Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol. 413(4):762-72.
  • Oki M, et al. (2011) A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 305656.
  • 주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".