MCP-1/CCL2  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Yeast  
50 µg 
20 µg 
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발현 숙주: Baculovirus-Insect cells  
50 µg 
20 µg 
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MCP-1/CCL2 Related Area

MCP-1/CCL2 관련 경로

MCP-1/CCL2 요약 및 단백질 정보

MCP-1/CCL2 배경

하부단위 구조: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. {ECO:0000269|PubMed:8898111}.
세포하 위치: Secreted.
유도: Up-regulated upon hypertonic conditions. {ECO:0000269|PubMed:23233732}.
번역 후: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
염기서열 유사성: Belongs to the intercrine beta (chemokine CC) family. {ECO:0000305}.
General information above from UniProt

Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, belongs to a group of CC chemokines located in chromosome 17q11.2. MCP-1 protein interacts with chemokine C-C motif receptor 2 (CCR2) to activate and recruit monocytes, macrophages, CD4+ T cells and immature dendritic cells to the site of infection [7–9]. The presence of MCP-1 protein in an adequate concentration is important for granuloma formation and M. tuberculosis clearance.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

MCP-1/CCL2 대체 이름

MCP-1/CCL2 관련 연구

주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".