CD112/Nectin-2/PVRL2  Protein, Antibody, ELISA Kit, cDNA Clone

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CD112/Nectin-2/PVRL2 Related Area

CD112/Nectin-2/PVRL2 관련 경로

    CD112/Nectin-2/PVRL2 요약 및 단백질 정보

    CD112/Nectin-2/PVRL2 배경

    유전자 요약: This PVRL2 gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. Nectin-2 is one of the plasma membrane components of adherens junctions. Nectin-2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    General information above from NCBI
    하부단위 구조: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000250, ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:15607800, ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:22927415}.
    세포하 위치: Cell membrane; Single-pass type I membrane protein.
    조직 특이성: Ubiquitous.
    염기서열 유사성: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    CD112/Nectin-2/PVRL2 대체 이름

    CD112/Nectin-2/PVRL2 관련 연구

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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