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CD166/ALCAM  단백질

All CD166 Reagents

발현 숙주: Human Cells  
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10045-H08H-100
10045-H08H-200
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발현 숙주: Human Cells  
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50005-M03H-50
50005-M03H-100
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발현 숙주: Human Cells  
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50005-M08H-50
50005-M08H-100
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100 µg 
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발현 숙주: Human Cells  
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80221-R08H-50
80221-R08H-100
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발현 숙주: Human Cells  
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80221-R02H-50
80221-R02H-100
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발현 숙주: Human Cells  
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90227-C02H-100
90227-C02H-50
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50 µg 
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발현 숙주: Human Cells  
  • Slide 1
90227-C08H-100
90227-C08H-200
100 µg 
200 µg 
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CD166/ALCAM 관련 제품

CD166/ALCAM 관련 제품

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CD166/ALCAM 요약 및 단백질 정보

CD166/ALCAM 배경

유전자 요약: This ALCAM gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
General information above from NCBI
도메인: The CD6 binding site is located in the N-terminal Ig-like domain.
세포하 위치: Membrane; Single-pass type I membrane protein.
조직 특이성: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.
염기서열 유사성: Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.C
General information above from UniProt

Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

CD166/ALCAM 대체 이름

CD166/ALCAM 관련 연구

  • Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21.
  • Fujiwara H, et al. (2003) Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). J Clin Endocrinol Metab. 88(7): 3437-43.
  • Jezierska A, et al. (2006) ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 12(8): BR263-73.
  • Kahlert C, et al. (2009) Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 101(3): 457-64.
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