CD30/TNFRSF8  Protein, Antibody, ELISA Kit, cDNA Clone

제품 설명: Active  
발현 숙주: Human Cells  
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
200 µg 
100 µg 
Add to Cart

CD30/TNFRSF8 Related Area

CD30/TNFRSF8 관련 경로

CD30/TNFRSF8 관련 제품

CD30/TNFRSF8 요약 및 단백질 정보


유전자 요약: The protein encoded by TNFRSF8 gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of TNFRSF8 gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
General information above from NCBI
하부단위 구조: Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:10518213, ECO:0000269|PubMed:8627180, ECO:0000269|PubMed:8999898, ECO:0000269|PubMed:9168896, ECO:0000269|PubMed:9511754}.
세포하 위치: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cytoplasm.
번역 후: Phosphorylated on serine and tyrosine residues.
염기서열 유사성: Contains 6 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD30/TNFRSF8 대체 이름

CD30,Ki-1,D1S166E, [homo-sapiens]
CD30,D1S166E,Ki-1,TNFRSF8, [human]
Ki,Cd30,D1S166E,Ki-1,RP23-306F22.1,Tnfrsf8, [mouse]
Ki,Cd30,Ki-1,D1S166E, [mus-musculus]

CD30/TNFRSF8 관련 연구

  • Rossi FM, et al. (2001) CD30L up-regulates CD30 and IL-4 expression by T cells. FEBS Lett. 508(3): 418-22.
  • Trovato M, et al. (2001) Expression of CD30 ligand and CD30 receptor in normal thyroid and benign and malignant thyroid nodules. Thyroid. 11(7): 621-8.
  • Ekstrom ES, et al. (2001) Presence of CD30(+) and CD30L(+) cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 22(4): 372-9.
  • Tang C, et al. (2008) A novel role of CD30L/CD30 signaling by T-T cell interaction in Th1 response against mycobacterial infection. J Immunol. 181(9): 6316-27.
  • Sun X, et al. (2008) A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice. Gastroenterology. 134(2): 447-58.
  • Oflazoglu E, et al. (2009) Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.Adv Exp Med Biol. 647: 174-85.
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