CD40/TNFRSF5  Protein, Antibody, ELISA Kit, cDNA Clone

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80151-R02H-50
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70105-D02H-50
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90097-C08H-50
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CD40/TNFRSF5 Related Area

CD40/TNFRSF5 관련 경로

CD40/TNFRSF5 관련 제품

CD40/TNFRSF5 요약 및 단백질 정보

CD40/TNFRSF5 배경

유전자 요약: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
General information above from NCBI
하부단위 구조: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation. {ECO:0000269|PubMed:10984535, ECO:0000269|PubMed:12005438, ECO:0000269|PubMed:2463309, ECO:0000269|PubMed:7530216, ECO:0000269|PubMed:7533327, ECO:0000269|PubMed:9432981, ECO:0000269|PubMed:9511754, ECO:0000269|PubMed:9718306}.
세포하 위치: Isoform I: Cell membrane; Single-pass type I membrane protein.; Isoform II: Secreted.
조직 특이성: B-cells and in primary carcinomas.
질병과의 관련성: DISEASE: Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections. {ECO:0000269|PubMed:11675497}. Note=The disease is caused by mutations affecting the gene represented in this entry.
염기서열 유사성: Contains 4 TNFR-Cys repeats. {ECO:0000255|PROSITE-ProRule:PRU00206}.
General information above from UniProt

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

CD40/TNFRSF5 대체 이름

p50,Bp50,CDW40,TNFRSF5, [homo-sapiens]
Bp50,CD40,CDW40,MGC9013,p50,TNFRSF5, [human]
p50,gp39,HIGM1,IGM,IMD3,T-BAM,TRAP,AI326936,Bp50,Cd40,RP23-428M13.1,Tnfrsf5, [mouse]
IGM,p50,Bp50,GP39,IMD3,TRAP,HIGM1,T-BAM,Tnfrsf5,AI326936, [mus-musculus]

CD40/TNFRSF5 관련 연구

  • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
  • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
  • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
  • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
  • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.
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