CD48/Blast-1  Protein, Antibody, ELISA Kit, cDNA Clone

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10797-H08H-50
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발현 숙주: Human Cells  
10797-H02H-50
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50415-M08H-50
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발현 숙주: Human Cells  
50415-M02H-50
50415-M02H-100
50 µg 
100 µg 
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발현 숙주: Human Cells  
80286-R02H-50
80286-R02H-100
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발현 숙주: Human Cells  
80286-R08H-50
80286-R08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

CD48/Blast-1 Related Area

CD48/Blast-1 관련 경로

    CD48/Blast-1 요약 및 단백질 정보

    CD48/Blast-1 배경

    유전자 요약: This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
    General information above from NCBI
    하부단위 구조: Interacts with CD244 in an heterophilic manner. {ECO:0000250}.
    세포하 위치: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
    염기서열 유사성: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD48/Blast-1 대체 이름

    Blast-1, []
    BCM1,BLAST,hCD48,mCD48,BLAST1,SLAMF2,MEM-102, [homo-sapiens]
    BCM1,BLAST,BLAST1,CD48,hCD48,mCD48,MEM-102,SLAMF2, [human]
    AI449234,AW610730,BCM1,Bcm-1,BLAST,BLAST1,BLAST-1,Cd48,MEM-102,Sgp-60,SLAMF2, [mouse]
    BCM1,BLAST,Bcm-1,BLAST1,SLAMF2,Sgp-60,BLAST-1,MEM-102,AI449234,AW610730, [mus-musculus]

    CD48/Blast-1 관련 연구

  • Messmer B, et al. (2006) CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. J Immunol. 176(8): 4646-50
  • Milstein O, et al. (2008) Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem. 283(49): 34414-22.
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