CD73/NT5E  Protein, Antibody, ELISA Kit, cDNA Clone

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CD73/NT5E Related Area

CD73/NT5E 관련 경로

    CD73/NT5E 요약 및 단백질 정보

    CD73/NT5E 배경

    유전자 요약: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. CD73 is used as a determinant of lymphocyte differentiation. Defects in this NT5E gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
    General information above from NCBI
    촉매 활성: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
    보조 인자: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    하부단위 구조: Homodimer. {ECO:0000269|PubMed:23142347}.
    세포하 위치: Cell membrane; Lipid-anchor, GPI-anchor.
    번역 후: Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation in glucose-stimulated insulinoma cells (By similarity).
    질병과의 관련성: DISEASE: Calcification of joints and arteries (CALJA) [MIM:211800]: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. {ECO:0000269|PubMed:21288095}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    염기서열 유사성: Belongs to the 5'-nucleotidase family. {ECO:0000305}.
    General information above from UniProt

    5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein which belongs to the 5'-nucleotidase family. CD73 is a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes. CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. CD73 serves as a costimulatory molecule in activating T cells. CD73 generated adenosine functions in cell signalling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses. CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function. In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1 and E-selectin increase. CD73 produces extracellular adenosine, which then acts on G protein-coupled purigenic receptors to induce cellular responses. CD73 has also been reported to regulate expression of pro-inflammatory molecules in mouse endothelium.

    CD73/NT5E 대체 이름

    CALJA, []
    NT,eN,NT5,NTE,eNT,CD73,E5NT,CALJA, [homo-sapiens]
    5'-nucleotidase,CD73,E5NT,ecto-5'-nucleotidase,eN,NT5,5'-NT,eNT,NT,NT5E,NTE,RP11-321N4.1, [human]
    2210401F01Rik,AI447961,CD73,ecto-5'-nucleotidase,eNT,NT,Nt5,5'-NT,Nt5e,5'-nucleotidase, [mouse]
    NT,Nt5,eNT,CD73,AI447961,2210401F01Rik, [mus-musculus]

    CD73/NT5E 관련 연구

  • Resta R. et al., 1997, Cell Signal. 9 (2): 131-9.
  • Yamashita Y. et al., 1998, Eur J Immunol. 28 (10): 2981-90.
  • Louis NA. et al., 2008, J Immunol. 180 (6): 4246-55.
  • Grünewald JK. et al., 2010, J Inflamm. 7 (1): 10.
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