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CD74 Antibody, Rabbit MAb

데이터시트리뷰관련제품프로토콜
Human CD74 항체 제품 정보
면역원:Recombinant Human CD74 protein (Catalog#11091-H07H)
Clone ID:301
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Human CD74 (rh CD74; Catalog#11091-H07H; NP_004346.1; Gln73-Met232).
Human CD74 항체 사용 가이드
특이성:Human CD74
적용:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CD74. The detection limit for Human CD74 is approximately 0.078 ng/well.

IHC-P: 1-10 μg/mL

보관:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CD74 Antibody IHC Application Image
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Caption:
Immunochemical staining of human CD74 in human colon carcinoma with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
CD74 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human CD74 in human gastric cancer with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
CD74 Antibody, Rabbit MAb, Immunohistochemistry
Other CD74 Antibody Products
CD74 연구배경

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD74, also known as HLA class2 histocompatibility antigen gamma chain and HLA-DR antigens-associated invariant chain, is a polypeptide involved in the formation and transport of MHC class2 protein. CD74 is expressed by B cells, macrophages, and Reed-Sternberg cells. When MHC class 2 protein was in the rough ER, its peptide-binding cleft was blocked by CD74 to prevent it from interacting with the endogenous peptides. CD74 also serves to facilitate MHC class2's export from ER.

Human CD74 참고자료
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Moynes R, et al. (1997) A marker to distinguish atypical fibroxanthoma from malignant fibrous histiocytoma. Cancer. 79 (11): 2115-24.
  • Gabrielle FA, et al. (2008) Regulation of dendritic cell migration by CD74, the MHC class 2-associated invariant chain. Science. 322 (5908): 1705-10.
  • Leng L, et al. (2003) MIF signal transduction initiated by binding to CD74. JEM.197 (11): 1467-76.
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    Cat No: 11091-R301-50
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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