All B7-1 reagents are produced in house and quality controlled, including 22 B7-1 Antibody, 52 B7-1 Gene, 8 B7-1 Lysate, 8 B7-1 Protein, 3 B7-1 qPCR. All B7-1 reagents are ready to use.
Recombinant B7-1 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc, C-human IgG1-Fc & His, C-cleavage.
B7-1antibodies are validated with different applications, which are FCM, ELISA, WB, IHC-P.
B7-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each B7-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets