CD96/TACTILE  Protein, Antibody, ELISA Kit, cDNA Clone

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발현 숙주: Human Cells  
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11202-H08H-20
11202-H08H-100
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100 µg 
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제품 설명: Active  
발현 숙주: Human Cells  
  • Slide 1
50758-M08H-50
50758-M08H-100
50 µg 
100 µg 
Add to Cart

CD96/TACTILE Related Area

CD96/TACTILE 관련 경로

    CD96/TACTILE 요약 및 단백질 정보

    CD96/TACTILE 배경

    유전자 요약: The protein encoded by this CD96 gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. CD96 may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. CD96 may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    하부단위 구조: Homodimer; disulfide-linked. Interacts with PVR. {ECO:0000269|PubMed:15034010}.
    세포하 위치: Membrane; Single-pass type I membrane protein.
    조직 특이성: Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
    발생 단계: Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus.
    질병과의 관련성: DISEASE: C syndrome (CSYN) [MIM:211750]: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears. {ECO:0000269|PubMed:17847009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
    염기서열 유사성: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), a nectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. The effect the cells with mutated CD96 protein lost adhesion and growth activities indicates that CD96 mutations may cause a form of the C syndrome by interfering with cell adhesion and growth.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD96/TACTILE 대체 이름

    TACTILE, [homo-sapiens]
    CD96,DKFZp667E2122,MGC22596,TACTILE, [human]
    1700109I12Rik,Cd96,Tactile, [mouse]
    Tactile,1700109I12Rik, [mus-musculus]

    CD96/TACTILE 관련 연구

  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12
  • Anja Fuchs, et al. (2004) Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155). The Journal of Immunology.172 (7): 3994-8.
  • Seth S, et al.(2007) The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochemical and Biophysical Research Communications. 364 (4): 959-65.
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