CDK16/PCTK1/PCTAIRE1  Protein, Antibody, ELISA Kit, cDNA Clone


CDK16/PCTK1/PCTAIRE1 요약 및 단백질 정보


유전자 요약: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
General information above from NCBI
촉매 활성: ATP + a protein = ADP + a phosphoprotein.
하부단위 구조: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with NSF. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with BRSK2. Interacts with CCNY; this increases the CDK16 kinase activity.
세포하 위치: Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome (By similarity). Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
조직 특이성: Detected in pancreas islets (at protein level). Detected in brain and pancreas.
번역 후: Phosphorylation at Ser-153 inhibits kinase activity.
염기서열 유사성: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.
General information above from UniProt



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