CDK8  Protein, Antibody, ELISA Kit, cDNA Clone

CDK8 Related Area

CDK8 관련 경로

CDK8 요약 및 단백질 정보

CDK8 배경

촉매 활성: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:10993082}.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. {ECO:0000269|PubMed:10993082}.
보조 인자: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
하부단위 구조: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. Interacts with CTNNB1, GLI3 and MAML1. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15546612, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:17000779, ECO:0000269|PubMed:21806996, ECO:0000269|PubMed:9734358}.
세포하 위치: Nucleus {ECO:0000305}.
염기서열 유사성: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

CDK8 대체 이름

K35, [homo-sapiens]

CDK8 관련 연구

주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".