All CEACAM5 reagents are produced in house and quality controlled, including 15 CEACAM5 Antibody, 1 CEACAM5 ELISA, 13 CEACAM5 Gene, 3 CEACAM5 Lysate, 3 CEACAM5 Protein, 1 CEACAM5 qPCR. All CEACAM5 reagents are ready to use.
Recombinant CEACAM5 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His.
CEACAM5antibodies are validated with different applications, which are FCM, WB, ELISA, IHC-P, ELISA(Cap), ELISA(Det).
CEACAM5cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CEACAM5 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CEACAM5ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.