CEACAM5/CEA/CD66e  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Human Cells  
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발현 숙주: Human Cells  
  • Slide 1
50 µg 
100 µg 
Add to Cart

CEACAM5/CEA/CD66e Related Area

CEACAM5/CEA/CD66e 관련 경로

    CEACAM5/CEA/CD66e 요약 및 단백질 정보

    CEACAM5/CEA/CD66e 배경

    유전자 요약: Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).
    General information above from NCBI
    하부단위 구조: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.
    세포하 위치: Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185}.
    조직 특이성: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
    번역 후: Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
    염기서열 유사성: Belongs to the immunoglobulin superfamily. CEA family. {ECO:0000305}.; Contains 7 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CEACAM5/CEA/CD66e 대체 이름

    1600029H12Rik,Psg30, []
    CEA,CD66e, [homo-sapiens]
    CD66e,CEACAM5,DKFZp781M2392,CEA, [human]
    Psg30,1600029H12Rik, [mus-musculus]

    CEACAM5/CEA/CD66e 관련 연구

  • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
  • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
  • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.
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