Hemojuvelin cDNA ORF Clone, Rhesus, C-Myc tag

Cat: CG90061-CM
Contact us:
215-583-7898
order@sinobiological.com
Distributors
All Hemojuvelin Reagents
CRO Services
Product recommended

All Hemojuvelin Reagents
Hemojuvelin cDNA ORF Clone, Rhesus, C-Myc tag General Information
Gene
Species
Rhesus
NCBI Ref Seq
RefSeq ORF Size
1284 bp
Description
Full length Clone DNA of Rhesus hemochromatosis type 2 (juvenile) with C terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-Myc
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

Hemojuvelin Background Information

Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).

Full Name
hemochromatosis type 2 (juvenile)
References
  • Papanikolaou G, et al. (2004) Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 36(1):77-82.
  • Babitt JL, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 38(5):531-9.
  • Zhang AS, et al. (2008) Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane. J Biol Chem. 283(25):17494-502.
  • Hemojuvelin cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Rhesus CG90061-G
    Hemojuvelin cDNA ORF Clone, Rhesus, untagged CG90061-UT
    Hemojuvelin cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90061-ACG
    Hemojuvelin Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90061-ACGLN
    Hemojuvelin cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90061-ACR
    Hemojuvelin cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90061-CF
    Hemojuvelin cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90061-NF
    Hemojuvelin cDNA ORF Clone, Rhesus, C-His tag CG90061-CH
    Hemojuvelin cDNA ORF Clone, Rhesus, N-His tag CG90061-NH
    Hemojuvelin cDNA ORF Clone, Rhesus, C-HA tag CG90061-CY
    Hemojuvelin cDNA ORF Clone, Rhesus, N-HA tag CG90061-NY
    Hemojuvelin cDNA ORF Clone, Rhesus, N-Myc tag CG90061-NM

    Hemojuvelin cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Rat RG80142-G
    Hemojuvelin cDNA ORF Clone, Rat, untagged RG80142-UT
    Hemojuvelin Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80142-ACGLN
    Hemojuvelin cDNA ORF Clone, Rat, C-GFPSpark® tag RG80142-ACG
    Hemojuvelin cDNA ORF Clone, Rat, C-OFPSpark® tag RG80142-ACR
    Hemojuvelin cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80142-CF
    Hemojuvelin cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80142-NF
    Hemojuvelin cDNA ORF Clone, Rat, C-His tag RG80142-CH
    Hemojuvelin cDNA ORF Clone, Rat, N-His tag RG80142-NH
    Hemojuvelin cDNA ORF Clone, Rat, C-HA tag RG80142-CY
    Hemojuvelin cDNA ORF Clone, Rat, N-HA tag RG80142-NY
    Hemojuvelin cDNA ORF Clone, Rat, C-Myc tag RG80142-CM
    Hemojuvelin cDNA ORF Clone, Rat, N-Myc tag RG80142-NM
    Hemojuvelin qPCR Primer Pairs, Rat RP300137

    Hemojuvelin cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    Hemojuvelin cDNA ORF Clone in Cloning Vector, Human HG10410-M
    Hemojuvelin cDNA ORF Clone, Human, untagged HG10410-UT
    Hemojuvelin cDNA ORF Clone, Human, C-GFPSpark® tag HG10410-ACG
    Hemojuvelin Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10410-ACGLN
    Hemojuvelin cDNA ORF Clone, Human, C-OFPSpark® tag HG10410-ACR
    Hemojuvelin cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10410-CF
    Hemojuvelin cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10410-NF
    Hemojuvelin cDNA ORF Clone, Human, C-His tag HG10410-CH
    Hemojuvelin cDNA ORF Clone, Human, N-His tag HG10410-NH
    Hemojuvelin cDNA ORF Clone, Human, C-HA tag HG10410-CY
    Hemojuvelin cDNA ORF Clone, Human, N-HA tag HG10410-NY
    Hemojuvelin cDNA ORF Clone, Human, C-Myc tag HG10410-CM
    Hemojuvelin cDNA ORF Clone, Human, N-Myc tag HG10410-NM
    Hemojuvelin qPCR Primer Pairs, Human HP100440
    info info
    添加购物车成功! 添加购物车失败!