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Cystatin C / CST3 항체, 토끼 단클론항체

데이터시트리뷰관련제품프로토콜
Rat CST3 항체 제품 정보
면역원:Recombinant Rat Cystatin C / CST3 protein (Catalog#80040-R08H)
Clone ID:001
면역글로불린(Ig) 유형:Rabbit IgG
농도:
내독소:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
제조방법:This antibody was obtained from a rabbit immunized with purified, recombinant Rat Cystatin C / CST3 (rR Cystatin C / CST3; Catalog#80040-R08H; P14841-1; Met1-Ala140).
Rat CST3 항체 사용 가이드
특이성:Rat Cystatin C / CST3
Has cross-reactivity in ELISA with
Mouse CST3
No cross-reactivity in ELISA with
Human CST3
적용:IHC-P

IHC-P: 1-10 μg/mL

보관:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Rat CST3 Antibody IHC Application Image
Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of rat CST3 in rat brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
[이미지를 확대하려면 클릭]
Caption:
Immunochemical staining of rat CST3 in rat kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other CST3 Antibody Products
Cystatin C / CST3 연구배경

Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal function, particularly to detect small reductions in glomerular filtration rate. The mature, active form of human cystatin C is a single non-glycosylated polypeptide chain consisting of 120 amino acid residues, with a molecular mass of 13,343-13,359 Da, and containing four characteristic disulfide-paired cysteine residues. Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of Cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. In almost all the clinical studies, Cystatin C demonstrated a better diagnostic accuracy than serum creatinine in discriminating normal from impaired kidney function, but controversial results have been obtained by comparing this protein with other indices of kidney disease, especially serum creatinine-based equations, such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases. Cystatin C could be a useful clinical tool to identify HIV-infected persons. In addition, its expression is up-regulated in malignance of certain tumor progression.

Rat Cystatin C / CST3 참고자료
  • Mares J, et al. (2003) Use of cystatin C determination in clinical diagnostics. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 147(2): 177-80.
  • Mussap M, et al. (2004) Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci. 41(5-6): 467-550.
  • Sronie-Vivien S, et al. (2008) Cystatin C: current position and future prospects. Clin Chem Lab Med. 46(12): 1664-86.
  • Taglieri N, et al. (2009) Cystatin C and cardiovascular risk. Clin Chem. 55(11): 1932-43.
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    Cat No: 80040-R001-50
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    • Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
    • Cystatin C / CST3 Antibody, Rabbit MAb, Immunohistochemistry
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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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