DKK1/Dkk-1  Protein, Antibody, ELISA Kit, cDNA Clone

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발현 숙주: Human Cells  
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10170-H08H-20
10170-H08H-100
10170-H08H-5
20 µg 
100 µg 
5 µg 
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발현 숙주: Human Cells  
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57248-M08H-10
57248-M08H-50
10 µg 
50 µg 
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11089-K08H-100
11089-K08H-20
11089-K08H-5
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20 µg 
5 µg 
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발현 숙주: Human Cells  
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11089-K05H-5
11089-K05H-100
11089-K05H-20
5 µg 
100 µg 
20 µg 
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DKK1/Dkk-1 관련 경로

DKK1/Dkk-1 요약 및 단백질 정보

DKK1/Dkk-1 배경

유전자 요약: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.
General information above from NCBI
하부단위 구조: Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling.
도메인: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity).
세포하 위치: Secreted.
조직 특이성: Placenta.
염기서열 유사성: Belongs to the dickkopf family.
General information above from UniProt

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

DKK1/Dkk-1 대체 이름

SK,DKK-1, [homo-sapiens]
S,Dickkopf 1,DKK1,DKK-1,hDKK 1,SK, [human]
mdkk-1, [mus-musculus]

DKK1/Dkk-1 관련 연구

  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
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