Epidermal Growth Factor/EGF  Protein, Antibody, ELISA Kit, cDNA Clone

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10605-H01H-500
10605-H01H-100
10605-H01H-1
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100 µg 
1 mg 
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10605-HNAE-500
10605-HNAE-100
10605-HNAE-1
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1 mg 
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50482-M01H-500
50482-M01H-100
50482-M01H-1
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50482-M08H1-50
50482-M08H1-20
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20 µg 
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50482-MNAY-500
50482-MNAY-100
50482-MNAY-1
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1 mg 
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50482-MNCH-500
50482-MNCH-100
50482-MNCH-1
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80446-RNAE-500
80446-RNAE-100
80446-RNAE-1
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70013-D07E-500
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70013-D07E-1
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100 µg 
1 mg 
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Epidermal Growth Factor/EGF Related Area

Epidermal Growth Factor/EGF 관련 경로

Epidermal Growth Factor/EGF 요약 및 단백질 정보

Epidermal Growth Factor/EGF 배경

유전자 요약: This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.
General information above from NCBI
하부단위 구조: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2 (By similarity). Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). {ECO:0000250, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21029725, ECO:0000269|PubMed:21439629}.
세포하 위치: Membrane; Single-pass type I membrane protein.
조직 특이성: Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269|PubMed:17671655}.
번역 후: O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor). {ECO:0000269|PubMed:22171320}.
질병과의 관련성: DISEASE: Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269|PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.
염기서열 유사성: Contains 9 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 9 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}.
General information above from UniProt

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

Epidermal Growth Factor/EGF 대체 이름

Epidermal Growth Factor, []
URG,HOMG4, [homo-sapiens]
EGF,HOMG4,URG, [human]
AI790464,Egf, [mouse]
AI790464, [mus-musculus]

Epidermal Growth Factor/EGF 관련 연구

  • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
  • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
  • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
  • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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