FCRL1/FCRH1  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Human Cells  
11536-H08H-50
11536-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
50947-M08H-50
50947-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

FCRL1/FCRH1 Related Area

FCRL1/FCRH1 관련 경로

    FCRL1/FCRH1 요약 및 단백질 정보

    FCRL1/FCRH1 배경

    유전자 요약: This FCRL1 gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. FCRL1 contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. FCRL1 may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    General information above from NCBI
    세포하 위치: Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
    조직 특이성: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level). {ECO:0000269|PubMed:11493702, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
    유도: Down-regulated in activated B-cells. {ECO:0000269|PubMed:15479727}.
    번역 후: Phosphorylated on tyrosines upon activation. {ECO:0000269|PubMed:15479727}.
    염기서열 유사성: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    Fc receptor-like protein 1, also known as FcR-like protein 1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5 and FCRL1, is a single-pass type I  membrane protein which contains three Ig-like C2-type (immunoglobulin-like) domains. It is a cell-surface membrane protein belonging to FCRL family and is preferentially expressed on B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It is detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. FCRL1 is specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level). Human Fc receptor-like molecules (FCRL1, FCRL2, FCRL3, FCRL4, FCRL5) have tyrosine-based immunoregulatory potential and are expressed by B-lineage subpopulations. FCRL1 may function as an activating coreceptor in B cells. It may also function in B cells activation and differentiation.

    FCRL1/FCRH1 대체 이름

    FCRH1,IFGP1,IRTA5,CD307a, [homo-sapiens]
    DKFZp667O1421,FCRH1,FCRL1,IRTA5,IFGP1, [human]
    Fcrh1,Fcrh1l,Fcrh1s,Fcrl1,Ifgp1,A230020G22Rik,Bxmas1,Bxmh1,Bxmh1b, [mouse]
    Bxmh1,Fcrh1,Ifgp1,Bxmas1,Bxmh1b,Fcrh1l,Fcrh1s,A230020G22Rik, [mus-musculus]

    FCRL1/FCRH1 관련 연구

  • Du X. et al., 2008, Blood. 111 (1): 338-43.
  • Kazemi T. et al., 2008, Int J Cancer. 123 (9): 2113-9.
  • Baranov K. et al., 2008, J Immunol Methods. 332 (1-2): 73-81.
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