FCRL3  Protein, Antibody, ELISA Kit, cDNA Clone

FCRL3 Related Area

FCRL3 관련 경로

    FCRL3 요약 및 단백질 정보

    FCRL3 배경

    하부단위 구조: Interacts with PTPN6, PTPN11, SYK and ZAP70. {ECO:0000269|PubMed:12051764}.
    세포하 위치: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
    조직 특이성: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level). {ECO:0000269|PubMed:11493702, ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16849395}.
    번역 후: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. {ECO:0000269|PubMed:12051764}.
    질병과의 관련성: DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16176992, ECO:0000269|PubMed:16476711, ECO:0000269|PubMed:16859508, ECO:0000269|PubMed:17133579, ECO:0000269|PubMed:17179172, ECO:0000269|PubMed:17763442}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.; DISEASE: Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism.
    염기서열 유사성: Contains 6 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    FCRL3 대체 이름

    CD307c,FCRH3,IFGP3,IRTA3,SPAP2, []

    FCRL3 관련 연구

    주의 : 모든 제품은 "연구 목적만을 위한 것이며 진단이나 치료에 사용하도록 의도되지 않았습니다".