All FGFR2 reagents are produced in house and quality controlled, including 8 FGFR2 Antibody, 2 FGFR2 ELISA, 28 FGFR2 Gene, 8 FGFR2 Lysate, 8 FGFR2 Protein, 1 FGFR2 qPCR. All FGFR2 reagents are ready to use.
Recombinant FGFR2 proteins are expressed by HEK293 Cells, Baculovirus-Insect Cells with fusion tags as C-human IgG1-Fc & His, C-His, N-GST & His, C-human IgG1-Fc.
FGFR2antibodies are validated with different applications, which are ELISA, ELISA(Det), ELISA(Cap).
FGFR2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each FGFR2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
FGFR2ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: Baculovirus-Insect Cells
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.