PSMA cDNA ORF Clone in Cloning Vector, Human General Information
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 223 T/C resulting in the amino acid Tyr substitution by His and 333 A/T, 732 T/C not causing the amino acid variation.
Full length Clone DNA of Human folate hydrolase (prostate-specific membrane antigen) 1.
SP6 and T7 or M13-47 and RV-M
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
PSMA cDNA ORF Clone in Cloning Vector, Human Alternative Names
FGCP cDNA ORF Clone, Human;FOLH cDNA ORF Clone, Human;GCP2 cDNA ORF Clone, Human;GCPII cDNA ORF Clone, Human;mGCP cDNA ORF Clone, Human;NAALAD1 cDNA ORF Clone, Human;NAALAdase cDNA ORF Clone, Human;PSM cDNA ORF Clone, Human;PSMA cDNA ORF Clone, Human
PSMA Background Information
Glutamate carboxypeptidase 2, also known as Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, Prostate-specific membrane antigen, GCPII, PSMA, FOLH1, and NAALAD1, is a single-pass type I I membrane protein which belongs to the peptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, brain (at protein level), and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease, neural tube defects, and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
folate hydrolase (prostate-specific membrane antigen) 1
Israeli R.S., et al.,(1993), Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53:227-230. Su S.L., et al., (1995), Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression.Cancer Res. 55:1441-1443. O'Keefe D.S., et al.,(1998), Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.Biochim. Biophys. Acta 1443:113-127.