FcERI/FCER1A  Protein, Antibody, ELISA Kit, cDNA Clone

발현 숙주: Human Cells  
13193-H08H-50
13193-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
발현 숙주: Human Cells  
50935-M02H-50
50935-M02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

FcERI/FCER1A Related Area

FcERI/FCER1A 관련 경로

    FcERI/FCER1A 요약 및 단백질 정보

    FcERI/FCER1A 배경

    유전자 요약: The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by FCER1A gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
    General information above from NCBI
    하부단위 구조: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.
    세포하 위치: Cell membrane; Single-pass type I membrane protein.
    염기서열 유사성: Contains 2 Ig-like (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.

    FcERI/FCER1A 대체 이름

    FCE1A,FcERI, [homo-sapiens]
    alpha polypeptide,Fc epsilon RI alpha-chain,Fc IgE receptor,FCE1A,Fc-epsilon RI-alpha,FcERI,high affinity immunoglobulin epsilon receptor alpha-subunit,high affinity immunoglobulin epsilon receptor subunit alpha,high-affinity,igE Fc receptor subunit alpha,immunoglobulin E receptor,of mast cells,RP11-550P17.3, [human]
    Fce1a,fc-epsilon RI-alpha,fcepsilonri,FcERI,Fcr-5,high affinity immunoglobulin epsilon receptor subunit alpha,igE Fc receptor subunit alpha, [mouse]
    FcERI,Fce1a,Fcr-5,fcepsilonri, [mus-musculus]

    FcERI/FCER1A 관련 연구

  • Shikanai T, et al. (2002) Sequence variants in the FcepsilonRI alpha chain gene. J Appl Physiol. 93(1):37-41.
  • Sada K, et al. (2002) Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells. Blood. 100(6):2138-44.
  • Takahashi K, et al. (2003) Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. Mol Immunol. 38(16-18):1193-9.
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