GABA-transaminase/ABAT cDNA Clone: Expression and Clone Vector / Plasmid
GABA-transaminase/ABAT cDNA / Gene Overview
ABAT cDNA / gene is a gene with protein product which located on 16p13.2. The ABAT gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog. 242 organisms have orthologs with human gene ABAT.
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
GABA-transaminase/ABAT cDNA / Gene Sequence
HUMGABAT 1705 bp mRNA linear PRI 11-AUG-1995
Human 4-aminobutyrate aminotransferase (GABAT) mRNA, complete cds.
This sequence information is just for reference only.
GABA-transaminase/ABAT cDNA / Gene Alias
GABA-transaminase/ABAT cDNA / Gene Expression
Biased expression in liver (RPKM 93.2), kidney (RPKM 61.6) and 11 other tissues
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