GCSH (Protein | Antibody | cDNA Clone | ELISA Kit)

All GCSH reagents are produced in house and quality controlled, including 6 GCSH Antibody, 30 GCSH Gene, 1 GCSH Protein, 1 GCSH qPCR. All GCSH reagents are ready to use.

GCSH Protein (1)

GCSH Antibody (6)

GCSH cDNA Clone (30)

GCSH qPCR Primer (1)

GCSH Background

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). GCSH is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in GCSH gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for GCSH gene. Also, several transcribed and non-transcribed pseudogenes of GCSH gene exist throughout the genome.

GCSH References

  • Hiraga K. et al., 1988, Biochem Biophys Res Commun. 151 (2): 758-62.
  • Fujiwara K. et al., 1991, Biochem Biophys Res Commun. 176 (2): 711-6.
  • Koyata H. et al., 1991, Am J Hum Genet. 48 (2): 351-61.