Anti-Her2 / ERBB2 Antibody (Biotin)

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Anti-Her2 / ERBB2 Antibody (Biotin) (Mouse Monoclonal antibody) General Information

Product name
Anti-Her2 / ERBB2 Antibody (Biotin)
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Her2 / ERBB2
No cross-reactivity in ELISA with Human ErbB1 / EGFR, Human ErbB3 / HER3, Human ErbB4 / HER4and Human cell lysate (293 cell line)
Immunogen
Recombinant Human ErbB2 protein (Catalog#10004-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ErbB2 / HER2 extracellular domain (rhErbB2; Catalog#10004-H08H; NP_004439.2; Met 1-Thr 652). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated.
Source
Monoclonal Mouse IgG2a Clone #8B5D4C1
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Biotin
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Her2 / ERBB2 Antibody (Biotin) (Mouse Monoclonal antibody) Validated Applications

Application Dilution
ELISA 0.5-1 μg/mL
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Her2 / ERBB2 Antibody (Biotin): Alternative Names

Anti-CD340 Antibody; Anti-ENV Antibody; Anti-ENVW Antibody; Anti-ERVWE1 Antibody; Anti-HER-2 Antibody; Anti-HER-2/neu Antibody; Anti-HER2 Antibody; Anti-HERV-7q Antibody; Anti-HERV-W-ENV Antibody; Anti-HERV7Q Antibody; Anti-HERVW Antibody; Anti-HERVWENV Antibody; Anti-MLN 19 Antibody; Anti-MLN19 Antibody; Anti-NEU Antibody; Anti-NGL Antibody; Anti-TKR1 Antibody

Her2 / ERBB2 Background Information

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Full Name
erb-b2 receptor tyrosine kinase 2
References
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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