CD5L cDNA ORF Clone, Human, N-Myc tag General Information
Full length Clone DNA of Human CD5 molecule-like with N terminal Myc tag.
Enhanced CMV promoter
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
CD5L cDNA ORF Clone, Human, N-Myc tag Alternative Names
AIM cDNA ORF Clone, Human;API6 cDNA ORF Clone, Human;PRO229 cDNA ORF Clone, Human;SP-ALPHA cDNA ORF Clone, Human;Spalpha cDNA ORF Clone, Human
CD5L Background Information
CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis.
Resnick, D. et al., 1994, Trends Biochem. Sci. 19: 5-8. Gebe, J. A. et al., 1997, J. Biol. Chem. 272 (10): 6151–6158. Sarrias, M.R. et al., 2004, Crit. Rev. Immunol. 24: 1-37. Mukhopadhyay, S. and Gordon, S., 2004, Immunobiology 209: 39-49. Sarrias, M. R. et al.,2005, J. Biol. Chem. 280 (42): 35391–35398.