FOLR2 cDNA ORF Clone, Human, N-DDK (Flag®) tag General Information
Identical with the Gene Bank Ref. ID sequence.
Full length Clone DNA of Human folate receptor 2 (fetal) with N terminal Flag tag.
Enhanced CMV promoter
KpnI + XbaI(6kb+0.81kb)
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
FOLR2 cDNA ORF Clone, Human, N-DDK (Flag®) tag Validated Images
FOLR2 cDNA ORF Clone, Human, N-DDK (Flag®) tag Alternative Names
BETA-HFR cDNA ORF Clone, Human;FBP cDNA ORF Clone, Human;FBP/PL-1 cDNA ORF Clone, Human;FR-BETA cDNA ORF Clone, Human;FR-P3 cDNA ORF Clone, Human
FOLR2 Background Information
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potocytosis. FOLR2 has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.
folate receptor 2 (fetal)
van Heyningen V, et al., 1995, Cytogenet Cell Genet. 69 (3-4): 127-58. Sabharanjak, S. et al., 2004, Adv Drug Deliv Rev. 56 (8): 1099-109. Scapoli, L. et al., 2005, Am J Med Genet A. 132A (3): 302-4. Puig-Kröger, A. et al., 2009, Cancer Res 69 (24): 9395-403.