휴먼 HER2 / ErbB2 단백질

  • Human HER2 / ErbB2 Protein
데이터시트리뷰관련제품프로토콜
휴먼 ERBB2 단백질 제품 정보
동의어:CD340,HER-2,HER-2/neu,HER2,MLN 19,MLN19,NEU,NGL,TKR1
단백질 구조:A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Thr652) was expressed with five amino acids (DDDDK) at the C-terminus.
:Human
발현 숙주:Human Cells
양식 및 배송:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
휴먼 ERBB2 단백질 품질 관리 검사
순도:> 95 % as determined by SDS-PAGE.
생리활성:1.Measured by its binding ability in a functional ELISA.
2.Immobilized human ErbB2 (Cat:10004-HCCH) at 10μg/mL (100μL/well) can bind herceptin ,the EC50 of herceptin is 7-90ng/mL.
내독소:< 1.0 EU per μg protein as determined by the LAL method.
안정성:Samples are stable for up to twelve months from date of receipt at -70℃
예상된 N 말단(N Terminal):Thr 23
분자량:The recombinant human ERBB2 consists 636 amino acids and predicts a molecular mass of 70 kDa.
Formulation:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
휴먼 ERBB2 단백질 사용 가이드
보관:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
복원:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
휴먼 ERBB2 Protein SDS-PAGE
Human HER2 / ErbB2 Protein
Other ERBB2 Recombinant Protein Products
HER2/ERBB2 연구배경

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

휴먼 HER2/ERBB2 참고자료
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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    Size / Price
    Cat No: 10004-HCCH-50
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    Datasheet & Documentation

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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
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